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Dr. Garry Shen MD, PhD

Shen

Dr. Garry Shen is a full Professor in the Section of Endocrinology and Metabolism, Departments of Internal Medicine, Physiology and Pathophysiology and Human Nutritional Sciences in University of Manitoba. He obtained his undergraduate and postgraduate degrees in Shanghai Second Medical University. He has received research training in University of Iowa, Cleveland Clinic Research Institute, University of Alberta and Harvard Medical School. He became a faculty member of University of Manitoba since 1991 and has been the Associate Director of Diabetes Research Group since 1998, and Co-Chair of Endocrine Research Group in 2015 His research program has been supported by Canadian Institutes of Health Research, Public Health Agency of Canada, Canadian Diabetes Association, Heart and Stroke Foundation. He has published >100 full sizes papers or book chapters in the field of atherosclerosis, thrombosis, diabetes vascular complications, nutrition, gestational diabetes and prenatal care. He has received a numbers of career awards including Alberta Heritage Foundation Postdoctoral Fellowship Award, New Investigator Award from Canadian Lipoprotein Conference, and Iacocca Visiting Professor Award from Joslin Diabetes Center. He has served on a number of grant review committees including CIHR, CDA, HSF, PHAC and Lawson Foundation. He has been served as the Editor-in-Chief of Cardiovascular and Hematological Disorders-Drug Targets Journal, Editorial Board member for Canadian Journal of Diabetes, Councillor and Chair of Trainee Advisory Committee of CSATVB (Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology).

 

Research interests:

 

  • Atherosclerosis and lipoprotein metabolism
  • Diabetic vascular complications
  • Endothelial cell biology
  • Mitochondrial biology
  • Oxidative stress and antioxidants
  • Type 2 diabetes and gestational diabetes
  • Thrombosis and anti-thrombotic peptides
  • Nutritional intervention for preventing diabetic complications
  • Community-based life-style intervention on obesity and diabetes

 

 

Selected publications since 2010:

 

Roy Chowdhury SK, Sangle GV, Xie X, Halayko AJ, Stelmark G, Shen GX.

Effect of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab. 2010;298:E89-98.

 

Tang XF, Liu JJ, Wu YL, Chen KM, Jin Y, Gao PJ, Zhu DL, Shen GX. Effect of hirulog-like peptide on balloon catheter injury induced neoinitimal formation in femoral arteries of minipigs. J Vasc Res 2010;47:262-269.

 

Sangle GV, Roy Chowdhury SK, Xie X, Halayko AJ, Stelmark G, Shen GX.

Impairment of mitochondrial respiratory chain activity in aortic endothelial cells induced by glycated LDL. Free Radical Biology and Medicine. 2010;48:781-790

 

Sangle GV, Zhao R, Misuno T, Shen GX. Involvement of RAGE, NADPH oxidase and Ras/Raf-1 pathway in glycated LDL-induced expression of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells. Endocrinology 151:4455-66

 

Zhao R, Moghadasian M, Shen GX.              Involvement of NADPH Oxidase in Upregulation of Plasminogen Activator Inhibitor-1 and Heat Shock Factor-1 in Mouse Embryo Fibroblasts Induced by Oxidized LDL and in Apolipoprotein E-Deficient Mice. Free Radical Res 2011;45:1013-23

 

Hui A, Back L, Ludwig S, Gardiner P, Sevenhuysen G, Dean H, Sellers E, McGavock J, Morris M, Bruce S, Murry R, Shen GX. Lifestyle intervention on diet and exercise reduced excessive gestational weight gain in pregnant women under a randomized controlled trial. Br J Obstetr Gynecol 2012;119:70-77

 

Xie X, Zhao R, Shen GX. Influence of delphinidin-3-glucoside on oxidized low density lipoprotein-indued oxidative sress and apoptosis in cultured endothelial cells. J Agric Food Chem 2012;60:1850-1856

 

Back L, Hui A, Reid A, Reid A, Sevnehuysen G, Gardiner P, Ludwig S, Shen GX. Comparison of Physical Activity and Nutritional Intake in First Nations Pregnant Women in Remote Communities and Urban-Living Pregnant Women. Can J Diabetes 2012;36:64-67

 

Xie X, Zhao R, Shen GX. Impact of Cyanidin-3-Glucoside on Glycated LDL-Induced NADPH Oxidase Activation, Mitochondrial Dysfunction and Apoptosis in Cultured Vascular Endothelial Cells. Int J Mol Sci 2012;13:15867-15880

 

Noble EG, Shen GX. Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation. Autoimmune Diseases, 2012, Article ID 836519, 2012. doi:10.1155/2012/836519.

 

Zhao R, Xie X, Shen GX. Effects of Glycated Low Density Lipoprotein on Cell Viability, Proliferation and Growth Factors in Mouse Embryo Fibroblasts. Can J Physiol Pharmacol 2013;91:64-70.

 

Zhao R, Le K, Moghadasian MH, Shen GX. Regulatory role of NADPH oxidase in glycated LDL-induced upregulaation of plasminogen activator inhibitor-1 and heat shock factor-1 in mouse embryo fibroblasts and diabetic mice. Free Rad Biol Mol 2013:61:18-25

 

Surendiran G, Goh  CY, Le K, Zhao Z, Askarian F, Othman R, Nicholson T, Moghadasian P,Wang YJ,  Aliani M, Shen GX, Beta B, Moghadasian HM. 2013

Wild rice (Zizania palustris L.) prevents atherogenesis in LDL receptor knockout mice. Atherosclerosis 2013;230:284:92.

 

Zhao R, Ren S, Moghadasain MH, Rempel JD, Shen GX. Involvement of Fibrinolytic Regulators in Adhesion of Monocytes to Vascular Endothelial Cells Induced by Glycated LDL and to Aorta from Diabetic Mice. J Leukocy Biol 2014;95(6):941-9.

 

Adamo KB, Shen GX, Mottola M, Nascimento S, Jean-Philippe S, Ferraro ZM, Nerenberg K, Smith G, Chari R, Gaudet L, Piccinini-Vallis H, Wolcott C, McDonald S, Atkinson S, Godbout A, Robitaille J, Davidge ST, Gruslin A, Prud’homme D, Stacey D, Rossiter M, Goldfield GS, Dodd J. Obesity Prevention from Conception: a workshop to guide the development of a pan Canadian trial targeting the gestational period.  J Nutr Metab Insights 2014;7:7-18.

 

Eskicioglu P, Halas, Jénéchal M, Wood L, McKay E, Villeneuve S, Shen GX, Dean H, McGavock, J. Peer mentoring for Type 2 Diabetes Prevention in First Nations children.

Pediatrics 2014;133(6):e1624-31

 

Zhao R, Le K, Li W, Ren S, Moghadasian MH, Beta T, Shen GX. Effects of Saskatoon Berry Powder on Monocyte Adhesion to Vascular Wall of Leptin        Receptor-Deficient Diabetic Mice. J Nutr Biochem. 2014;25(8):851-857 PMID: 24925752

 

Wang RY, Lin XJ, Yang GY, Gao PJ, Shen GX. Effect of Hirulog-like peptide on middle cerebral artery occlusion-induced brain injury in mice. Neuroscience. 2014;277:568-76

 

Hui AL, Back L, Ludwig S, Gardiner P, Sevenhuysen G, Dean HJ, Sellers E, McGavock J, Morris M, Jiang D, Shen GX. Effects of lifestyle intervention on dietary intake, physical activity level, and gestational weight gain in pregnant women with different pre-pregnancy Body Mass Index in a randomized control trial. BMC Pregnancy Childbirth. 2014;331;14:331.

 

Reid A, Back L, Hui A, McGavock J, Dean H, Ludwig S,  Sellers E, Shen GX. Reducing barriers for pregnant women in rural or remote First Nations communities to      participate in prenatal nutrition and exercise programs. J Fam Med Commun Health 1(4):1020

 

 

Senechal M, Rempel M, Duhamel TA, MacIntosh AC, Hay J, Wicklow B, Wittmeier K, Shen GX, McGavock JM. Fitness is a Determinant of the Metabolic Response to Endurance Training in Adolescents at Risk of Type 2 Diabetes Mellitus. Obesity 2015;23(4):823-32.